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BACKGROUND: Glycogen Storage Disease (GSD) Types Ia and Ib are rare metabolic diseases caused by gene variants in G6PC1 and SLC37A4, respectively. Although life-threatening fasting hypoglycemia can be controlled by a strict diet, patients often …
Read PDFPyrroloquinoline quinone (<b>PQQ</b>) is a bacterial redox cofactor enabling enzyme catalysis in various sugar and alcohol dehydrogenases. However, its proposed additional role as a "longevity vitamin" lacks a clear molecular basis and is thus highly …
Read PDFEndometriosis is a prevalent gynecologic disorder that significantly impacts women's health. However, its underlying pathogenesis remains unknown. This study aimed to ascertain causal associations between plasma protein levels and endometriosis using a Mendelian randomization (MR) …
Read PDF<h4>Background</h4>The search for new biomarkers that allow an early diagnosis in sepsis has become a necessity in medicine. This study aims to identify protein biomarkers that differentiate sepsis from non-infectious systemic inflammatory response syndrome (NISIRS), …
Read PDF<h4>Introduction</h4>This explanatory pilot study presents a workflow to identify approved drugs, which could be repurposed for periodontitis therapy using salivary proteomics combined with drug-target database screening.<h4>Methods</h4>Proteomic analyses of saliva using LC-MS/MS were conducted in two …
Read PDFTranslational cardiovascular medicine increasingly relies on systems-level approaches to uncover therapeutic targets that bridge molecular mechanisms and clinical outcomes. Recent proteomic analyses in experimental myocardial infarction models highlight how modulation of multiple protein networks can …
Read PDFTo identify specific, sensitive, and non-invasive circulating protein biomarkers that could facilitate the diagnosis of brain metastasis (BrM) and improve risk prediction for BrM among patients with non-small cell lung cancer (NSCLC). We performed data-independent …
Read PDF<h4>Background</h4>Low-volume trapping columns are essential for sample enrichment, desalting, and injection profile focusing on nano-LC-MS-based proteomics. They enable higher sample loading, improve chromatographic performance, and protect the analytical column by removing salts and contaminants. Recently, …
Read PDFMass spectrometry (MS)-based proteomics is a disruptive platform in drug discovery that offers an exhaustive view of the proteome's complexity. Focusing on bottom-up MS proteomics, this technology enables high-throughput analysis of protein expression, interactions, and …
Read PDF<b>BACKGROUND:</b> Liver injury is a frequent complication of heatstroke and constitutes a direct cause of death. However, only a few studies examined the mechanism underlying heatstroke-induced liver injury. <b>OBJECTIVE:</b> We aimed to evaluate the role …
Read PDFImmunoglobulin A (IgA) is the most abundant antibody in humans, with high concentrations in both mucosae/secretions and circulation. While mucosal IgA has been studied extensively, characterization of human IgA in serum and its distinctive functions …
Read PDF<h4>Purpose</h4>This study aimed to identify plasma exosomal protein biomarkers for early recognition of acute myocardial infarction (AMI) using label-free quantitative proteomics.<h4>Methods</h4>Patients presenting to the Second Affiliated Hospital of Soochow University with chest discomfort between February …
Read PDFMalaria is caused by protozoan parasites of the genus Plasmodium that proliferate asexually in human erythrocytes. During each replication cycle, a small fraction of the parasites differentiates into gametocytes. These sexual gametocytes are the only …
Read PDFBACKGROUND: Fushen Granule (FSG), a Chinese medicine formular, was used clinically to improve the efficiency of dialysis in end-stage renal disease patients receiving peritoneal dialysis treatment. However, the mechanisms of its antifibrotic effect on peritoneal …
Read PDFRotator cuff tears are one of the most common shoulder disorders and can lead to pain, weakness, and limited mobility. Although the clinical condition has been widely studied, its molecular mechanisms are still not fully …
Read PDFAltered metabolism is a hallmark of cancer, making metabolic enzymes attractive therapeutic targets. However, metabolic inhibitors have shown limited clinical success, partly due to differences between standard culture media and physiological nutrient conditions. Human plasma-like …
Read PDFThe National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC) recently generated harmonized genomic, transcriptomic, proteomic, and clinical data for over 1,000 tumors across 10 cohorts to facilitate pan-cancer discovery research. However, protein expression comparison …
Read PDFStressful events are a leading factor in the development of depression. The medial prefrontal cortex (mPFC) is strongly associated with depression etiology and exposure to uncontrollable stressors results in synaptic dysfunction and loss. Learned helplessness …
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