Search the literature by keyword, topic, or author. Filter to articles with full text available.
3689 results
Elevated oxidative stress (OS) is a primary driver of ocular neurodegeneration, worsening with age-related declines in gonadal hormones. While the loss of endogenous 17β-estradiol (E2) is a recognized risk factor for retinal degeneration in females, …
Read PDFPoint-of-care diagnostic tools, such as lateral flow assays (LFAs), play a critical role in disease management and outbreak control. LFAs detect the presence of target antigens in disease-relevant biofluids, utilizing nanoparticles (termed detection probes) to …
Read PDF<h4>Background/aim</h4>Breast cancer is the most frequently diagnosed cancer among women. While biomarkers are critical for early detection and therapy, current markers lack sufficient specificity and sensitivity. The endoplasmic reticulum (ER) plays a central role in …
Read PDF<h4>Purpose</h4>Pharmacodynamic biomarkers of sirolimus were investigated using omics analysis of tear fluids from Japanese patients with meibomian gland dysfunction (MGD).<h4>Methods</h4>In a Phase 2a trial, sirolimus or vehicle eyedrops were administered twice daily for 12 weeks. …
Read PDF<h4>Background</h4>Sarcoidosis is a heterogeneous disease with unknown mechanisms, nonspecific therapies, and multiple etiologies. The role of blood extracellular vesicles (EVs) in the diagnosis and pathogenesis of sarcoidosis remains obscure. AIMS. This study aims to test …
Read PDF<b>Background/Objectives:</b> The clinical management of bladder cancer is severely impeded by high recurrence rates and the rapid emergence of chemoresistance, necessitating the discovery of novel therapeutic agents with distinct mechanisms of action. Dehydrodiisoeugenol (DHE), a …
Read PDFThe efficiency of rosmarinic acid (RA) in treating bleomycin (BLM)-induced pulmonary fibrosis (PF) was reported, but mechanisms are unclear. RA, from Herba japonica, is used for air-inflammatory and fibrotic diseases like PF. Its anti-inflammatory and …
Read PDFOBJECTIVES: In Inclusion Body Myositis (IBM), myofibers undergo structural and functional changes, including increased regeneration, atrophy, and fibrosis. The molecular mechanisms driving pathologically -associated fibers (PAF) remain poorly understood. METHODS: We developed a myofiber-level proteomic …
Read PDF<h4>Purpose</h4>The purpose of this study was to investigate candidate regulatory proteins associated with the pathogenesis of pterygium and to explore their potential biological roles.<h4>Methods</h4>Paired pterygium and conjunctival tissues from the discovery cohort (n = 10) …
Read PDFCoprophagy is an innate behavior of rabbits, and rabbit meat is favored by consumers for its distinctive nutritional characteristics. However, the relationship between coprophagy and meat quality in rabbits remains unclear. Therefore, this study investigated …
Read PDFBACKGROUND: Nasopharyngeal carcinoma (NPC) remains highly sensitive to radiotherapy; however, radioresistance in a subset of patients leads to local recurrence and distant metastasis. Serum proteomics provides a minimally invasive approach to capturing dynamic physiological changes, …
Read PDFAllergen cross-contact risk can arise when the oil used to roast peanuts is reused. Heat-induced protein denaturation reduces the accuracy of immunochemical methods; therefore, the objective of this study was to develop a targeted proteomics …
Read PDFPlasma proteomic biomarkers hold significant promise for enhancing clinical assessments and improving early detection of psychosis conversion; however, concerns about their reproducibility and generalizability persist. Previous studies, largely conducted in Caucasian cohorts, have identified proteomic …
Read PDFHeart failure with preserved ejection fraction (HFpEF) is a heterogeneous and increasingly prevalent syndrome that remains challenging to diagnose and risk-stratify using conventional clinical and echocardiographic parameters. Advances in high-throughput proteomic and metabolomic technologies, combined …
Read PDFCarbon dots offer excellent physico-chemical properties and biocompatibility for cancer theranostics systems, either as therapeutic agents themselves, or as potential drug carriers. It is, however, postulated that the drug carrier affects the mechanism of action …
Read PDFThis study aims to analyze the global research landscape and identify emerging trends in research hotspots, key technologies, and clinical applications in proteomics research in aging from 1998 to June 20, 2025. Publications related to …
Read PDF<h4>Background</h4>Development of therapies for CLN3 disease, a rare pediatric lysosomal storage disorder, has been hindered by the lack of etiological insights and translatable biomarkers to clinics.<h4>Methods</h4>We used a deep multi-omics approach to discover blood-based biomarkers …
Read PDF<h4>Background</h4>Glioma was the most common malignant tumor of the central nervous system in adults. Low-grade gliomas (LGGs) have a potential of grade progression and histological transformation, and the relevant mechanisms of this malignant evolution were …
Read PDFPlant membrane steroid binding proteins (MSBPs) belong to the membrane-associated progesterone receptors (MAPRs), which is present in all eukaryotic kingdoms. Plant MSBPs have been shown to regulate the function of cytochrome P450 enzymes, bind different …
Read PDF