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Plasmacytoid dendritic cells (pDCs) are specialized antiviral sentinels defined by rapid type I interferon (IFN‑I) production, yet their proteomic organization and metabolic requirements remain incompletely understood. We established the steady‑state proteome of murine splenic pDCs …
Read PDFFatty acid esters of hydroxy fatty acids (FAHFAs) are bioactive lipids with antidiabetic and anti-inflammatory effects, but the mechanisms responsible for their transport in blood are not well understood. In this study, we investigated potential …
Read PDF<h4>Background</h4>Dynamic modulation of α5-GABAAR expression and synaptic distribution plays a pivotal role in neuronal homeostatic plasticity, critically influencing memory processes. This study aims to investigate the spatiotemporal dynamics of α5-GABAAR in hippocampal subregions (CA1, CA3, …
Read PDFLung cancer is the leading cause of cancer-related deaths in the United States, and ~50% of these patients present with metastatic disease at diagnosis. Epithelial-to-Mesenchymal Transition (EMT) is an important initiating step in the metastatic …
Read PDF<h4>Background</h4>Bacterial infections remain a major global health burden, causing significant morbidity and mortality. Despite ongoing advances, prompt diagnosis is still hampered by nonspecific host biomarkers and the inherently slow turnaround of traditional microbiological cultures. These …
Read PDFTissue breakdown, especially extracellular matrix or secretome breakdown is a significant aspect of physiological remodeling and disease processes in solid organs, with profound structural and regulatory impact. Tissue and circulating proteins undergo breakdown through a …
Read PDFLipid droplets (LDs) are subcellular structures that occur in all plant cells and are composed of a core of hydrophobic molecules, such as triacylglycerols, surrounded by a phospholipid monolayer and various associated proteins. In recent …
Read PDFInsulin acts on adipocytes to suppress lipolysis and increase glucose uptake to control whole-body glucose and lipid metabolism. Regulation of these processes by insulin signalling depends on changes in protein localisation. However, the extent of …
Read PDFMass-based filtering significantly reduces the peptide candidate pool for subsequent scoring in database search algorithms. While useful, filtering based on one property may lead to exclusion of non-abundant spectra and uncharacterized peptides – potentially exacerbating …
Read PDF<h4>Background</h4>Tuberculous pleural effusion (TPE) results from an inflammatory response triggered by tuberculosis infection. If not promptly diagnosed and treated, it can lead to severe pulmonary dysfunction and the risk of infection spread. However, TPE diagnosis …
Read PDFBased on data-independent acquisition (DIA) proteomics technology, to analyze the proteomic characteristics of colorectal tubular adenoma and explore the expression changes of SLC30A10 and their potential association with the cGAS-STING pathway. A self-controlled design was …
Read PDFA plethora of studies suggest that a high-fat diet in combination with a high amyloid load causes synaptic insulin resistance and is a risk factor for Alzheimer's disease. Our understanding of the underlying mechanisms is …
Read PDF<b>Background:</b> Cang-ai volatile oil (CAVO) is a traditional Chinese medicine with properties that soothe the liver and alleviate depression. CAVO is widely utilized in the field of antidepressant research and has surfaced as a possible …
Read PDFPancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, driven by profound molecular heterogeneity and resistance to current therapy. To support systematic target identification, we established a proteomics-anchored knowledge discovery framework integrating cross-model …
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Read PDF[This corrects the article DOI: 10.3389/fcell.2025.1502469.].
Read PDFIntermittent fasting (IF) has emerged as a powerful dietary intervention with profound metabolic benefits, yet the tissue-specific molecular mechanisms underlying these effects remain poorly understood. In this study, we employed comprehensive proteomics and transcriptomics analysis …
Read PDFUnderstanding the pathophysiological substrates of schizophrenia is a major challenge for current neuropsychiatric research. As part of a set of multi-omics experiments, we performed an extensive case-control proteomics study on 192 post-mortem tissue sections from …
Read PDFWooden Breast (WB) and White Striping (WS) are prevalent myopathies affecting the <i>Pectoralis major</i> (PM) muscle of modern broiler chickens, with significant implications for animal welfare and meat quality. This pilot study aimed to characterize …
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