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Transcriptional interference is rarely documented in bacteria. In cyanobacteria, phycobilisomes are the major light-harvesting antennae, and their degradation under non-optimal conditions follows a tightly regulated genetic program leading to the production of NblA, a widely …
Read PDF<h4>Background</h4>Melanoma shows one of the highest response rates to immune checkpoint inhibitors (ICIs), yet nearly half of patients experience primary or acquired resistance. While immune contexture strongly influences therapeutic efficacy, tumor cell-intrinsic features are increasingly …
Read PDFIn Staphylococcus aureus, the quorum‑sensing accessory gene regulator (agr) system is the major virulence regulator. The four agr‑types (I-IV) have been associated with distinct infection outcomes, but their direct contribution to virulence regulation and metabolism …
Read PDFThe Muscovy duck (Cairina moschata) is an excellent lean-type poultry species characterized by large body weight, rapid growth, high lean meat yield, good liver production performance, and high feed conversion efficiency. It plays an important …
Read PDFTissue stiffening is central to disease progression and aggressiveness in pancreatic adenocarcinoma (PDAC). Here we report how the biomechanical characteristics of the cell culture conditions impact the amount, as well as the cargo, of extracellular …
Read PDFTransposable elements constitute a large portion of plant genomes and, due to their ability to change their genomic localization, they largely contribute to genome evolution and adaptability. Miniature inverted-repeat transposable elements (MITEs), due to their …
Read PDFThe increasing evidence that non-coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein-coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, …
Read PDFAPOBEC2 is a well-conserved member of the AID/APOBEC family of cytidine deaminases. Most members of the family catalyze the conversion of cytosine to uracil either in DNA or RNA, thereby acting as DNA mutators and/or …
Read PDFThe exceptional virulence of the human malaria parasite, Plasmodium falciparum, is attributed to the adhesive properties of infected red blood cells and the parasite's ability to avoid antibody recognition through antigenic variation. Both properties are …
Read PDFBladder cancer is a fast-moving and recurrent malignancy where survival hinges on early detection and precise risk stratification. The search for robust biomarkers is urgent, and CD44v6 has emerged as a compelling candidate. In this …
Read PDFC-type lectin receptors (CLRs) are a family of pattern recognition receptors that sense diverse microbial and damage-associated molecular patterns. Many CLRs, like Mincle and Dectin-3, are upregulated by TLR4 signaling. In Alcohol-associated Hepatitis (AH), where …
Read PDFZika viral replication vesicles (VRVs) were previously observed to cluster asymmetrically on one side of the nucleus in infected Huh7, A549, and h-NPCs. West Nile virus (WNV) infections in these cells also induce asymmetrically clustered …
Read PDFOzBarley is a comprehensive genotype-to-phenotype resource to support research and enhance barley breeding by integrating genotypic and phenotypic data for gene discovery. This publicly available dataset comprises genotypic data from historical and modern elite barley …
Read PDFKidney size is sex-dimorphic and regulated by androgens in adult humans and mice. However, the effects of developmental androgen deficiency on kidneys remain elusive. We hypothesized that androgens program future kidney growth during fetal development. …
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Read PDFOmacetaxine mepesuccinate (OMX), formerly known as homoharringtonine, is a protein translation inhibitor approved for use in human chronic myeloid leukemia. Recent studies suggest that OMX may be effective against other cancer types, and may be …
Read PDFHere, we report the complete mitochondrial genome of <i>Cossura pygodactylata</i> Jones 1956 (Annelida, Sedentaria, Cossuridae) (20,713 bp) comprised of two ribosomal RNAs, the ubiquitous set of 13 protein-coding genes (PCGs), 24 tRNAs, and a long …
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