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GEMS presents a framework for transforming genomic observations into traceable, reproducible, and auditable evidence for regulatory decision-making. It defines an eleven-stage lifecycle, six evidentiary pillars, and the Genomic Evidence Standard (GES), demonstrated through a portable …
Read PDFEarly detection of colorectal cancer (CRC) via population-based screening programs can reduce incidence and mortality. Current screening approaches are limited by cost, accessibility, compliance, and colonoscopy capacity. Blood-based screening of circulating tumor (ct) DNA may …
Read PDFColorectal cancer (CRC) is one of the most common and deadliest cancers worldwide, and incidence rates are rising. However, early detection and intervention can improve the survival rates and quality of life of affected patients. …
Read PDF<h4>Purpose</h4>To summarize current challenges in rare disease (RD) diagnosis and therapy, highlight recent advances in artificial intelligence (AI) for RDs, and propose a model future state for RD patient care.<h4>Methods</h4>Multidisciplinary expert-led narrative review summarizing modern …
Read PDF<h4>Background</h4>Low vitamin D (vitD) levels are consistently associated with an increased risk of depression. However, the biological mechanisms underlying this relationship and potential shared genetic overlap remain elusive.<h4>Methods</h4>We investigated the genetic overlap and causal relationships …
Read PDFNo one is perfect, and this is particularly true of disease classifications. When diseases are classified according to different dimensions (topography, symptoms, morphology, aetiology, etc), some characteristics of the diseases are prioritised while others are …
Read PDF<h4>Background</h4>Multi-epitope vaccines have become the preferred strategy for protection against infectious diseases by integrating multiple MHC-restricted T-cell and B-cell epitopes that elicit both humoral and cellular immune responses against pathogens. Computational methods address various aspects …
Read PDF(1) Precision Nursing (PN) emerges as an innovative field within Nursing. (2) PN represents the shift from standardized care to a highly tailored approach. (3) Nursing is strategically positioned to lead the translation of these …
Read PDFHenoch-Schönlein purpura (HSP) is an inflammatory condition affecting the small blood vessels, leading to organ damage and symptoms across various body systems, including skin, joints, and kidneys. The disease's pathogenesis involves the deposition of immunoglobulin …
Read PDF[This corrects the article DOI: 10.3389/fcell.2024.1494398.].
Read PDFLactate is not only the end product of glycolysis but also plays a key role in epigenetic regulation. Recently, lactate-derived histone lactylation has been identified as a novel epigenetic modification that can directly influence gene …
Read PDF<h4>Background & aims</h4>The contribution of activated hepatic stellate cells (aHSCs) to cholestatic fibrosis and cancer is well-documented, but the role of portal fibroblasts (PFs), and especially mesothelin (Msln)-mucin 16 (Muc16)- Thy-1 cell surface antigen (Thy-1) …
Read PDFThe 47th Annual Conference and the Golden Jubilee Year Meeting of the Environmental Mutagen Society of India (EMSI) and International Conference on Environmental and Molecular Mutagenesis: Genomic Integrity and Implication to Human Health was held …
Read PDFRenal biopsies remain indispensable in the diagnosis and management of renal diseases, offering critical histopathological insights that guide clinical decisions. Recent advances in artificial intelligence (AI) and multi-omics technologies have begun to transform renal pathology …
Read PDFSingle-cell mapping of chromosomal accessibility patterns has recently led to improved predictive modelling of epigenomic activity from sequence. However, quantitative models explaining the epigenome using directly interpretable components are still lacking. Here we develop IceQream …
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